POISED: Spotting Twitter Spam Off the Beaten Paths

Cybercriminals have found in online social networks a propitious medium to spread spam and malicious content. Existing techniques for detecting spam include predicting the trustworthiness of accounts and analyzing the content of these messages. However, advanced attackers can still successfully evade these defenses. Online social networks bring people who have personal connections or share common interests to form communities. In this paper, we first show that users within a networked community share some topics of interest. Moreover, content shared on these social network tend to propagate according to the interests of people. Dissemination paths may emerge where some communities post similar messages, based on the interests of those communities. Spam and other malicious content, on the other hand, follow different spreading patterns. In this paper, we follow this insight and present POISED, a system that leverages the differences in propagation between benign and malicious messages on social networks to identify spam and other unwanted content. We test our system on a dataset of 1.3M tweets collected from 64K users, and we show that our approach is effective in detecting malicious messages, reaching 91% precision and 93% recall. We also show that POISED's detection is more comprehensive than previous systems, by comparing it to three state-of-the-art spam detection systems that have been proposed by the research community in the past. POISED significantly outperforms each of these systems. Moreover, through simulations, we show how POISED is effective in the early detection of spam messages and how it is resilient against two well-known adversarial machine learning attacks

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation (vol 5, 4999, 2014)

10.1038/ncomms16193NATURE COMMUNICATIONS9

Genome-wide association studies identify four ER negative-specific breast cancer risk loci

<p>Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a metaanalysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P= 2.1 x 10(-12) and LGR6, P = 1.4 x 10(-8)), 2p24.1 (P = 4.6 x 10(-8)) and 16q12.2 (FTO, P = 4.0 x 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P> 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.</p>